The latest hydrogel biomaterial can repair knee ca

2022-08-09
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New hydrogel biomaterials can repair knee cartilage

according to daily science on January 14, the Johns Hopkins University School of Medicine reported that they have developed a new hydrogel biomaterial, which is injected into bone holes in cartilage repair surgery, which can help stimulate the bone marrow of patients to produce stem cells and grow new cartilage. In clinical trials, the coverage rate of new cartilage reached 86%, and the postoperative pain was greatly reduced. Relevant papers were published in Science Translational Medicine published on January 9

there is a thin layer of cartilage at both ends of the human articular bone, just like a film covering the bone. Trauma, wear, disease or genetic defects may damage the cartilage. Once the cartilage is damaged, it will not grow by itself. Microfracture surgery, also known as arthroscopic cartilage surgery, is to drill several small holes in the bone lacking cartilage coverage to stimulate bone marrow cells to produce stem cells to produce cartilage, and the Rockwell hardness value is calculated according to the following formula:. However, the operation may not be successful. It may not stimulate the growth of new cartilage, or the newly grown cartilage is not as hard as the original

in theory, stem cells need to be attached to a nutritional scaffold to grow better. Jennifereschiff, director of the center for translational tissue engineering (ttec) at Johns Hopkins University School of medicine, said that "hydrogel" scaffolds can provide "nutrition" to cells during the healing process, promote the growth of healthy tissues and accelerate wound healing. They conducted experiments in the laboratory and goats for many years to find the most ideal implant material that can be infinitely stretched. Finally, they selected a hydrogel biomaterial and an adhesive to make the hydrogel firmly adhere to the bone

the research team then conducted the first clinical trial on 15 patients. Through microfracture, some tiny holes were made in the bone near the injured cartilage, and hydrogels and adhesives were injected into them. For the control experiment, they only performed microfracture surgery on the other three patients. After 6 months, the implant did not cause major problems. MRI showed that the patients implanted with gel grew new cartilage, with an average coverage of 86% of the knee bones, and the average coverage of patients without gel was 64%. Moreover, the knee pain of patients implanted with gel was significantly reduced in 6 months after operation

"the preliminary research value is much lower. Research shows that the implanted biomaterials perform well in patients as well as in the laboratory, so Shandong Province has coverage. We hope this method can become a routine measure of nursing and promoting healing." Erichev said that this achievement is still a conceptual demonstration experiment. To prove the safety, effectiveness and clinical value of hydrogels, more time and larger-scale experiments are needed. At present, they have recruited more patients to participate in further experiments

Ehrlich also said that the research team is developing the next generation of transplantation materials, hydrogel and adhesive are one of them, and the two will be integrated into one material. In addition, they are also studying techniques to lubricate joints and reduce inflammation

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